Advances in renin-angiotensin-aldosterone system inhibitor (RAASi) therapy and its impact on various disease groups, particularly chronic kidney disease and heart failure, have been noteworthy, with recent studies showing that RAASi slows disease progression. , has been shown to have the potential to improve survival rates. In diabetic kidney disease.
In an interview with HCPLive, Kam Kalantar-Zadeh, MD, MPH, PhD, chief of the Division of Nephrology, Hypertension, and Transplantation at the University of California, Irvine Medical Center, talks about his presentation at the 2024 National Kidney Foundation (NKF) I will talk about the session. The Spring Clinical Meeting highlighted dietary challenges, potassium management, and potential solutions related to RAASi therapy. This session, conducted by two healthcare providers and a dietitian, will provide valuable insight to healthcare providers from a variety of disciplines and facilitate engaging discussions, which are essential to improving patient care and outcomes in clinical practice. The aim was to promote knowledge exchange.
Of note, two of the four classes of guideline-based drug therapy for chronic kidney disease management (GDMT) in diabetes constitute RAASis, highlighting their importance. Despite challenges such as hyperkalemia, Kalantar-Zadeh believes it is important not to abandon the prescribed RAASi dose and instead seek solutions such as dietary modifications and potassium-binding therapy. It emphasizes the need for interdisciplinary collaboration to explore.
Studies like FIDELIO have shown promising results in the management of diabetic kidney disease with RAASi therapy, despite the risk of hyperkalemia, and an effective potassium management strategy using specialized binding agents He explained that it will be reduced. Therefore, further studies are needed to optimize the dosage of RAASi.
“I think further research is needed to see how the use of potassium-binding therapy allows patients to tolerate and maximize their use of RAASi doses.” [while allowing] By reducing dietary restrictions, patients can enjoy a better quality of life,” said Qalantar Zadeh. “As we discussed, most potassium-rich diets are among the healthiest foods consistently recommended for cardiovascular health.”
Disclosure: Kalantar-Zadeh sporadically consults with Vifor Pharma.
